姚珂，女，中美（河南）荷美尔肿瘤研究院, 副教授。

研究方向：肿瘤发病机制及化学预防

地址：郑州市金水区东明路127号中美（河南）荷美尔肿瘤研究院

邮编：450001   

学习与工作经历：

1993-09 至 1998-06, 第四军医大学, 临床医学, 学士；1998-09 至 2001-06, 第四军医大学, 心血管病, 硕士；2007-09 至 2010-06, 郑州大学, 病理与病理生理学, 博士；2001-09 至 2004-01, 第四军医大学, 西京医院, 主治医师； 2004-01 至 2015-01, 荷美尔肿瘤研究院(美), 分子生物, 副教授； 2015-01 至今, 中美（河南）荷美尔肿瘤研究院, 分子生物, 副教授。

科研项目：

1. 河南省自然基金, 河南省自然基金, 162300410337, 查尔酮及黄酮类天然化合物靶向性预防及治疗非小细胞肺癌作用机制的研究, 2017-02 至 2018-08, 10万元, 结题, 主持

近年发表的SCI科研论文：

(1) Yao Ke ; Lee Sung Young; Peng Cong; Lim Do Young; Yamamoto Hiroyuki; Ryu Joohyun; Lim Tae Gyu; Chen Hanyong; Jin Guoguo; Zhao Zhenjiang; Han Yaping; Ma Wei Ya; Bode Ann M; Dong Zigang ; RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation., Oncogene, 2018, 37(26): 3501-3513 (期刊论文)

(2)  Yao, Ke; Peng, Cong; Zhang, Yuwen; Zykova, Tatyana A.; Lee, Mee-Hyun; Lee, Sung-Young; Ra o, Enyu; Chen, Hanyong; Ryu, Joohyun; Wang, Lei; Zhang, Yi; Gao, Ge; He, Wei; Ma, Wei-Ya; Liu, Kangdong; Bode, Ann M.; Dong, Ziming; Li, Bing; Dong, Zigang ; RSK2 phosphorylates T-bet to attenua te colon cancer metastasis and growth, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114(48): 12791-12796 (期刊论文)

(3)  Yoshitomi, Hisae; Lee, Kun Y; Yao, Ke; Shin, Seung Ho; Zhang, Tianshun; Wang, Qiushi; Paul, Souren; Roh, Eunmiri; Ryu, Joohyun; Chen, Hanyong ; GSK3β-mediated expression of CUG-translated WT1 is critical for tumor progression, Cancer Research, 2021, 81(4): 945-955 (期刊论文)

(4)  Jin, Guoguo; Yan, Mingyang; Liu, Kangdong; Yao, Ke; Chen, Hanyong; Zhang, Chengjuan; Yi,Yang; Reddy, Kanamata; Gorja, Dhilli Rao; Laster, Kyle Vaughn; Guo, Zhiping; Dong, Zigang ; Disco very of a novel dual-target inhibitor against RSK1 and MSK2 to suppress growth of human colon cancer, Oncogene, 2020, 39(43): 6733-6746 (期刊论文)

(5) Zhao, Simin; Yao, Ke; Li, Dan; Liu, Kangdong; Jin, Guoguo; Yan, Mingyang; Wu, Qiong; Chen, Hanyong; Shin, Seung Ho; Bai, Ruihua; Wang, Gangcheng; Bode, Ann M; Dong, Ziming; Guo, Ping; Dong, Zigang ; Inhibition of LTA4H by bestatin in human and mouse colorectal cancer, EBioMedicine, 2019, 44: 361-374 (期刊论文)